The first clinical trial of a generative AI therapy chatbot

United States

Dartmouth researchers have just published the first-ever clinical trial results of a generative AI therapy chatbot in NEJM AI—and the findings are genuinely promising:

• 51% average reduction in depression symptoms • 31% reduction in generalized anxiety symptoms • 19% reduction in eating disorder concerns

Participants in the study formed a “therapeutic alliance” with the AI chatbot (Therabot) comparable to what people report with human therapists. Many even initiated conversations during distressing moments, suggesting meaningful, sustained engagement.

While researchers emphasize that AI therapy is not a substitute for clinicians and must be deployed with careful oversight, the technology offers real potential to expand access to care - especially given that in the U.S., there’s currently just 1 provider for every 1,600 people with depression or anxiety.

This is exactly the kind of progress we need: rigorous clinical trials of AI in health care, not just speculation. While AI won’t solve all health care challenges, studies like this move the conversation forward showing us where technology can potentially complement human care in an evidence-based way. https://lnkd.in/dRaDXbXk

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Written by Tiago C. Peixoto. No agents involved – this predates the machinery. It first appeared on LinkedIn on April 2, 2025, and is reproduced here. Found an error? Tell me – corrections are logged.

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